LIRcentral is co-funded by the European Union (European Regional Development Fund, ERDF) and the Republic of Cyprus through the project EXCELLENCE/0421/0576 under the EXCELLENCE HUBS programme of the Cyprus Research and Innovation Foundation.
Protein: Calcium-binding and coiled-coil domain-containing protein 2
Uniprot ACC: Q13137
Species: Homo sapiens
| Up-stream | LIR Motif | Down-stream | Start position | End position | Type | (-2)LIR PSSM score | Exp. Verified (Functional YES/NO) |
|---|---|---|---|---|---|---|---|
| TSAVLLDHCH | FSQV | IFNSVEKFYI | 20 | 23 | F LIR | 0 | - |
| LDHCHFSQVI | FNSV | EKFYIPGGDV | 25 | 28 | F LIR | 0 | - |
| TQHFIPRRKD | WIGI | FRVGWKTTRE | 55 | 58 | W LIR | 19 | - |
| GWKTTREYYT | FMWV | TLPIDLNNKS | 72 | 75 | F LIR | 2 | - |
| KTTREYYTFM | WVTL | PIDLNNKSAK | 74 | 77 | W LIR xLIR | 20 | - |
| YLPKDDEYYQ | FCYV | DEDGVVRGAS | 107 | 110 | F LIR | 0 | - |
| EQLKKENDHL | FLSL | TEQRKDQKKL | 269 | 272 | F LIR | 4 | - |
| LKRENSRLLS | YMGL | DFNSLPYQVP | 348 | 351 | Y LIR | 6 | - |
| SRLLSYMGLD | FNSL | PYQVPTSDEG | 353 | 356 | F LIR | 10 | - |
| QNPGLAYGNP | YSGI | QESSSPSPLS | 380 | 383 | Y LIR | 3 | - |
| QFRPENEEDI | LVV | TTQGEVEEIE | 134 | 136 | non-canonical LIR | N/A | YES1 Ref. (4) |
Comments:
1DOI: 10.1016/j.molcel.2012.08.024: "Mutations of Leu134, Val135, or Val136, but not of Ile133 or other surrounding residues abrogated the interaction of NDP52 with LC3C in a LUMIER assay."
LIRcentral is co-funded by the European Union (European Regional Development Fund, ERDF) and the Republic of Cyprus through the project EXCELLENCE/0421/0576 under the EXCELLENCE HUBS programme of the Cyprus Research and Innovation Foundation.