Protein: Autophagy-related protein 3

Uniprot ACC: P40344

Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

S/N Up-stream LIR Motif Down-stream Start position End position Type (-2)LIR PSSM score Exp. Verified (Functional YES/NO)
1 YRDFLPKNKQ FLII RKVPCDKRAE 68 71 F LIR
9 -
2 GLAKDMAQER YYDL YIAYSTSYRV 168 171 Y LIR
6 -
3 NGSPLSPEQM FEDI SADYRTKTAT 202 205 F LIR
hfAIM(3)
10 -
4 EEQELDGVGD WEDL QDDIDDSLRV 270 273 W LIR
xLIR
hfAIM(3)
hfAIM(5)
22 YES1 Ref. (4)
5 DIDDSLRVDQ YLIV FLKFITSVTP 286 289 Y LIR
12 -

Comments:

1DOI: 10.4161/auto.7.3.14487: "The yeast Atg3 LIR motif (DWEDL) is required for transfer of Atg8 from the Atg8-Atg3 thioester intermediate to PE, but not for the formation of the intermediate. Interestingly, the Atg3 LIR is required for the Cvt pathway, but not for starvation-induced autophagy, and is important for lipidation of Atg8 that is bound to the Cvt pathway cargo receptor Atg19." DOI 10.1074/jbc.M110.113670: "These results clearly indicate that the WEDL sequence of Atg3 HR is a functional AIM and that Atg3 AIM directly interacts with Atg8 in a manner similar to Atg8-Atg19 AIM and LC3-p62 AIM interactions."